Graft – versus – host disease, diagnostika gastrointestinálnych komplikácii

AutoriNovotná T.

Pracovisko: GEK SZU, UNB, FNsP Petržalka  


Acute graft versus host disease (GVHD) occure within  100 days post bone marrow transplantation or haematopoetic stem cell transplantation. GVHD is a common complication associated with significant morbidity and mortality. Approximately 50% of patient who undergo allogeneic bone marrow transplantation are evaluated by a gastroenterologist  for gastrointestinal symptoms and sign. Early recognition and intervention may significantly improve the outcome of this patients. The diagnosis of gastrointestinal GVHD is based upon histologic findings in endoscopic mucosal biopsy. Our aim is to evaluate the sensitivity of simultaneus biopsy of the stomach, duodenum and rectosigmoid in establishing the diagnosis of GVHD.